Molecular epidemiology of tuberculosis in Havana, Cuba, 2009

Epidemiology of tuberculosis in Lorestan, 2008-2009

Background : Tuberculosis is known as one of the main causes of mortality worldwide. 1.7 milliard people worldwide are infected with TB germs, there are 8 million new cases of TB annually, and three million deaths occur due to the disease in developing countries. Materials and Methods: This study included all the cases who had referred to all the health centers of Lorestan province with posi...

Molecular epidemiology of antiretroviral resistance in therapy-experienced HIV-1 patients in Cuba (2009)

Results The most frequently found subtypes and recombinants were: B (40.4%), D (32.1%, presumably CRF19_cpx), C (9.5%) and CRF18_cpx (8.3%). The PI mutations, I54VML, M46IL and L90MVL were found in 61.7, 57.4 and 53.1% of cases, respectively. Whereas for RTI, primary mutations at positions M184V, T215Y, D67N, Y181C and K103N were present in 98.6, 67.1, 43.8, 47.5 and 40.9% of subjects, respecti...

Molecular Epidemiology in Tuberculosis

The M. tuberculosis pathogen is characterised by a thick, lipid-rich cell wall and membrane. It is a colonal organism, which means that it creates progeny that are very similar to each other. Today, we know that when M. tuberculosis grows and replicates, some of these progenies lose chunks of their DNA, and become slightly different. Genotyping is based on extracting the DNA from M. tuberculosi...

[Molecular epidemiology of tuberculosis].

Despite the almost 50 yrs since the introduction of curative antituberculosis drugs, Mycobacterium tuberculosis continues to exert an enormous toll on world health, and tuberculosis remains the world's leading cause of death due to a single infectious agent. This has stimulated research efforts into finding new tools to tackle the continuing tuberculosis pandemic. One of the few successes to da...

Molecular Epidemiology of Tuberculosis